Ungphakorn, W., Malmberg, C., Lagerbäck, P., Cars, O., Nielsen, E. I., & Tängdén, T. (2017).
Journal of Microbiological Methods, 132, 69-75
This study aimed to evaluate the potential of a new time-lapse microscopy based method (oCelloScope) to efficiently assess the in vitro antibacterial effects of antibiotics.
Two E. coli and one P. aeruginosa strain were exposed to ciprofloxacin, colistin, ertapenem and meropenem in 24-h experiments. Background corrected absorption (BCA) derived from the oCelloScope was used to detect bacterial growth. The data obtained with the oCelloScope were compared with those of the automated Bioscreen C method and standard time-kill experiments and a good agreement in results was observed during 6–24 h of experiments.
